Dr. Jenny J. Yang's Lab

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(104) You Zhuo, Kyril M. Solntsev, Florence Reddish, Shen Tang, and Jenny J. Yang. Effect of Ca2+ on the steady-state and time-resolved emission properties of the genetically encoded fluorescent sensor CatchER. Journal of Physical Chemistry B (2014). Accepted

(103). Yanyi Chen, Shenghui Xue,  Juan Zou, Jose R. Lopez, Jenny J. Yang and Claudio F. Perez. Myoplasmic resting Ca2+ regulation by RyR is under control of a novel Ca2+-binding region of the ryanodine receptor. Biochemical Journal (2014), In Press.

(102). Guifeng Qiang, Guanhua Du, Xiaobin Pang, Xiaoting Li, Shenghui Xue, Jenny J. Yang, Chi Bun Chan and Keqiang Ye,. Identification of a small molecular insulin receptor agonist with potent anti-diabetic activity. Diabetes (2014), 014 Apr; 63(4):1394-409. PMID:24651808

 (101). Shenghui Xue, Jingjuan Qiao, Jie Jiang, Lixia Wei, Shunyi Li, Kendra Hubbard, Natalie White, Zhiren Liu, Jenny J. Yang, Design of ProCAs (Protein-based Gd3+ MRI Contrast Agents) with High Dose Efficiency and Capability for Molecular Imaging of Cancer Biomarkers. Medical Research Review, (2014), Med Res Rev. 2014 Mar 11. doi: 10.1002/med.21313. PMID:24615853

(100) Chen Zhang,Yun Huang, Yusheng Jiang, Nagaraju Mulpuri, Ling Wei, Donald Hamelberg, Edward M. Brown, and Jenny J. Yang Positive cooperative responses of extracellular calcium to the calcium sensing receptor is globally enhanced by hetero-interaction of L-Phenylalanine, (2014)  Journal of Biological Chemistry,  Feb. 21 issue online Vol. 289, pp. 5296-5309.

(99). Juan Zou, Mani Salarian, Yanyi Chen,  Richard Veenstra Charles Louis, and Jenny J. Yang, Gap Junctions Regulation by Calmodulin. FEBS Letter, December (2013), Jan 16. pii: S0014- 5793 (14)00017-9. doi: 10.1016/j.febslet .2014.01.003.[Epub ahead of print] PMID:24440348

(98). Jingjuan Qiao, Shenghui Xue, Fan Pu, Natalie White, Jie Jiang, Zhiren  Liu, and Jenny J. Yang, Molecular Imaging of EGFR/ HER2 Cancer Biomarkers by Protein MRI Contrast Agents, Journal of Biological Inorganic Chemistry, (2014)  Feb;19(2):259-70. doi: 10.1007/ s00775 -013-1076-3. Epub 2013 Dec 24. PMID:24366655

(97).  Yusheng Jiang, Mulpuri Nagaraju, Rebecca C. Meyer, Li Zhang, Donald Hamelberg, Randy A. Hall, Edward M. Brown, P. Jeffrey Conn, and Jenny J. Yang. Extracellualr Calcium Modulates Actions of Orthosteric and Alloesteric Drugs on Metabotropoc Glutamate receptor 1 alpha. Journal of Biological Chemistry, (2014). Jan 17;289(3):1649-61. doi: 10.1074/jbc.M113.507665. Epub 2013 Nov 26. PMID: 24280223

(96). Ying Zhang, Florence Reddish, Shen Tang, You Zhuo, Yuanfang Wang, Jenny J. Yang, Irene T. Weber.  Structural Basis for Hand-Like Site of Calcium Sensor CatchER with Fast Kinetics. Acta Crystallogr D Biol Crystallogr. (2013).Dec;69(Pt 12):2309-19. Epub 2013 Nov19. PMID: 24311573.

(95). Xueliang Gao, Haizhen Wang, Jenny, J. Yang, Jing Chen, Jiang Jie, Liangwei Li,Yinwei Zhang, and Zhi-Ren Liu. Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals. Journal of Biological Chemistry (2013). 288(22):15971-9. doi: 10.1074/jbc.M112.448753. Epub 2013 Apr 10, PMID: 23576436.

(94). Michael Kirberger, Hing Wong, Jie Jiang and Jenny J Yang, Metal Toxicity and Opportunistic binding of Pb(II) in Proteins.  Journal of Bio-inorganic Chemistry (2013). 2013 Aug;125:40-9. doi: 10.1016/j.jinorgbio.2013.04.002. Epub 2013 Apr 19. PMID: 23692958.

(93). XueLiang Gao, Haizhen Wang, Jenny Yang, and Zhi-Ren Liu, Prevent Protein Interactions to Prevent Cancer Metastasis. Expert Review of Proteomics (10 (3) 2013),  Jun;10(3):207-9. doi: 10.1586/epr.13.17. PMID:23777209

(92) Haizhen Wang, XueLiang Gao, Jenny J. Yang, and Zhi-Ren Liu, Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis. Nature Communication (2013).  Jan 15;4:1354. doi: 10.1038/ ncomms 2345.PMID: 23322042

(91) Shenghui Xue, Jingjuan Qiao, Fan Pu, Mathew Cameron, and Jenny J. Yang, Design of a novel class of protein-based MRI contrast agents for the molecular imaging of cancer biomarkers, Wiley Interdiscip Rev Nanomed Nanobiotechnol. (WIREs) (2013) Mar;5(2):163-79. doi: 10.1002/wnan.1205. Epub 2013 Jan 17. PMID:23335551

(90). Ning Chen, Shen Tang, Shenhui Xue, and Jenny J. Yang, Protease sensors for Living Cells. Methods Navigators/Methods in Cell Biology, Wiley publisher 2012

(89). Yubin Zhou, Shenghui Xue, and Jenny J. Yang. Calciomics: integrative studies of Ca2+ binding proteins and their interactomes in biological systems. Metallomics, (2013) Jan;5(1):29-42. doi: 10.1039/c2mt20009k. PMID:23235533

(88). Yubin Zhou, Shenghui Xue, Yanyi Chen, and Jenny Yang, Probing Ca2+-binding Capability of Viral Proteins with the EF-hand motif by Grafting Approach: Methods Mol Biol. 2013;963:37-53. doi: 10.1007/978-1-62703-230-8_3. PMID:23296603.

(87). Shen Tang and Jenny J. Yang.  Types of Mg2+ Binding Sites in Proteins Encyclopedia for Metalloproteins. Eds. Vladimir Uversky, Robert Kretsinger, and Eugene A. Permyakov, Springer, 2012, In Press.

(86). Kun Zhao, Xue Wang, Hing Wong, Mike Kirberger, Robert Wohlheuter,  Guantao Chen, and Jenny J Yang,  Predicting Calcium-binding Sites Using Refined Carbon Atom.  Proteins: BioInformatics. (2012) Jul 21. 80(12):2666-79 doi: 10.1002/prot.24149. [Epub ahead of print] PMID:22821762

(85). Fadil M. Hannan, M. Andrew Nesbit, Chen Zhang, Alan J. Curley, Brian Harding, Treena Cranston, Carl Fratter, Nigel Rust, Paul T. Christie, Jeremy J.O. Turner, Manuel C. Lemos, Michael R. Bowl, Roger Bouillon, Caroline Brain, Nicola Bridges, Christine Burren, Alan L. Burshell, John M. Connell, Michael Davies, Stephen W. Jones, Heike Jung, Eileen Marks, David McCredie, Zulf Mughal, Christine Rodda, Sherida Tollefsen, John Tolmie, Edward M. Brown, Jenny J. Yang, Rajesh V. Thakker. Identification of 70 calcium-sensing receptor mutations in hypercalcaemic and hypocalcaemic patients: evidence for clustering of extracellular domain mutations at calcium binding sites. Human Molecular Genetics (2012). Jun 15;21(12):2768-78. Epub 2012 Mar 14. PMID:22422767

(84) Qin Xu, Richard F. Kopp, Yanyi Chen, Jenny J. Yang, Michael W. Roe, and Richard D. Veenstra, Gating of Connexin43 Gap Junctions by a Cytoplasmic Loop Calmodulin Binding Domain.  American Journal of Physiology - Cell Physiology, (2012). May;302(10):C1548-56. Epub 2012 Mar 14. PMID:22422398

(83). Xueliang Gao, Haizhen Wang, Jenny J Yang, Xiaowei Liu, Jie Jiang, and Zhiren Liu Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase Molecular Cell (2012) 45(5):598-609. Feb 1. [Epub ahead of print]. PMID:22306293. [ThIs paper was highlighted by: Leading edge in Cell Vol 148 issue 5, Feb 3rd (2012), Editor’s choice in Sci. Signal. Vol 5, Issue 216 p ec81 (2012), Research Highlight in Nature Reviews Molecular Cell Biology Vol 13, 139 (2012), and Preview in Molecular Cell Vol 45 p 583 (2012)].

(82). Yan Chen, Sunil Naik, Jurek Krzystek, Sooim Shin,  William Nelson,  Shenghui Xue, Jenny Yang, Victor L. Davidson, and Aimin Liu, Role of Calcium in Metalloenzymes: Effects of Ca2+ Removal on the Axial Ligation Geometry and Magnetic Properties of the Catalytic Diheme Center in MauG, Biochemistry (2012). 28;51(8):1586-97. Feb 8. [Epub ahead of print], PMID:22320333.

(81). Zhong-Min Wang, Shen Tang; Maria Messi, Jenny J. Yang, Osvaldo Delbono. Residual Sarcoplasmic Reticulum Ca2+ Concentration After Ca2+ Release in Skeletal Myofibers from Young-Adult and Old Mice. Pflugers Archiv-European Journal of Physiology (2011). 463(4):615-24 [Epub ahead of print] PMID:22249494.

(80). Michael Kirberger and Jenny J. Yang.  Calcium Binding Sites in Proteins: Types. Encyclopedia for Metelloproteins. Eds. Vladimir Uversky, Robert Kretsinger, and Eugene A. Permyakov, Springer, 2012, In Press.

(79). Yubin Zhou, Shenghui Xue, and Jenny J. Yang, Calcium and Viruses. Encyclopedia for Metelloproteins. Eds. Vladimir Uversky, Robert Kretsinger, and Eugene A. Permyakov, Springer, 2012, In Press.

(78).  Shunyi Li, Jie Jiang, Jin Zou,Jinjuan Qiao, Lixia Wei, Yubin Zhou, Shenghui Xue, Yanyi Chen, Robert Long, Liya Wang, Adriana Castiblanco, Natalie White, Jen Ngo, Wanda Zhou, Wei Ling, Hui Mao, Zhi-Ren Liu, and Jenny J. Yang. PEGylation of Protein MRI Contrast Agents Improves Relaxivity and Biocompatibilities.  Journal of Inorganic Biochemistry (2011). Nov 19;107(1):111-118. PMID:22178673

(77).  Shen Tang, Hing-Chueng Wong, Zhong-Min Wang, Yun Huang, Jin Zou, Andreas Pennati, Giovanni Gadda, Osvaldo Delbono, Jenny J. Yang, Design and Application of a Class of Sensors to Monitor Ca2+ dynamics in high Ca2+ concentration Cellular Compartments. Proc Natl Acad Sci U S A (2011). Sep 27; 108(39):16265-70. PMID: 21914846

(76). Jinjuan Qiao, Shunyi Li, Jie Jiang, Lixia Wei, Robert Liang, Liyia Wang, Hui Mao, Hua Yang, Hans Grossniklaus, Zhiren Liu and Jenny J. Yang. HER-2 Targeted Molecular MR Imaging Using a de novo Designed Protein Contrast Agent.  PLOS ONE (2011) Mar 24;6(3):e18103.PMID: 21455310

(75). Yanyi Chen, Yubin Zhou, Lin Xianming, Hing-Cheung Wong, Qin Xu, Jie Jiang, Siming Wang, Charles F. Louis, Richard Veenstra, and Jenny J. Yang, Molecular Interaction and Functional Regulation of Connexin50 Gap Junctions by Calmodulin. Biochemical Journal (2010).May 1;435(3):711-22. PMID:21320072.

(74). Jie Jiang, Yubin Zhou, Jin Zou, Yanyi Chen, Pryia Patel, Jenny J Yang, Edward M. Balog. Site-specific Modification of Calmodulin Ca2+ affinity Tunes the Skeletal Muscle Ryanodine Receptor Activation Profile. Biochemical Journal (2010), 432(1):89-99. PMID: 20815817.

(73). Yun Huang, Yubin Zhou, Adriana Castiblanco, Hing-Cheung Wong, Yangyi Chen, Edward M. Brown, and Jenny J. Yang. Calmodulin Binds to the Calcium-Sensing Receptor's Proximal C-terminus to Dynamically Regulate Cytosolic Ca2+ Signaling and Cell Surface Expression of the Receptor. Journal of Biological Chemistry. (2010). 285(46):35919-31. Epub 2010 Sep 8.PMID: 20826781

(72). Yusheng Jiang, Yun Huang, Hing Wong, Yubin Zhou, Xue Wang, Randy Hall, Edward Brown, Jenny J Yang, Elucidation of a Novel Extracellular Calcium Binding Site on Metabotropic Glutamate Receptor 1alpha that Controls Receptor Activation. Journal of Biological Chemistry. (2010). 285(43):33463-74. Epub 2010 Aug 12.PMID: 20705606.

(71). Xue Wang, Kun Zhao, Michael Kirberger, Hing Wong, Guantao Chen and Jenny J. Yang, Analysis and Prediction of calcium-binding pockets from Apo-Protein Structures Exhibiting Calcium-Induced Localized Conformational Changes. Protein Science (2010). 19(6):1180-90.PMID: 20512971

(70). Lixia Wei, Shunyi Li, Jianhua Yang, Yiming Ye, Jin Zou, Omar Zurkiya, Robert Long, Julian Johnson, Jingjuan Qiao, Adriana Castiblanco, Natalie Maor, Yangyi Chen, Wangda Zhou, Hui Mao, Xiaoping Hu, Jenny J. Yang, and Zhi-Ren Liu, Protein-based MRI Contrast Agents for Molecular Imaging of Prostate Cancer. Molecular Imaging  and Biology (2010). 32(5):521-5, Jun 24. [Epub ahead of print]PMID: 20574851

(69). Yubin Zhou, Wen-Pin Tzeng, Hing-Cheung Wong, Yiming Ye, Jie Jiang, Yanyi Chen, Yun Huang, Suganthi Suppiah, Teryl K. Frey, and Jenny J. Yang, Calcium-Dependent Association of Calmodulin with the Rubella Virus Nonstructural Protease Domain. Journal of Biological Chemistry (2010). 285(12):8855-68. Epub 2010 Jan 19.PMID: 20086014.

(68). Anna Wilkins Mannicia, Wei Yang, Julian A. Johnson, Shun-yi Li, Harianto Tjong, Huan-Xiang Zhou,  Lev A. Shaket, and Jenny Yang,  Inverse Tuning of Metal Binding Affinity and Protein Stability by Altering Charged Coordination Residues in Designed Calcium Binding Proteins, PMC Biophysics (2010). Dec 21;2:11.PMID: 20025729

(67). Yanyi Chen, Shenghui Xue, Yubin Zhou,Jenny J. Yang, Calciomics: Prediction and analysis of EF-hand Calcium-binding Proteins by Protein Engineering,  Science China Chemistry, (2010). January 1, 53 (1): 52-60.

(66).  Michael Kirberger, Xue Wang, Kun Zhao, Shen Tang, Guantao Chen, and Jenny J Yang Integration of Diverse Research Methods to Analyze and Engineer Ca2+-binding Proteins: From Prediction to Production.  Current Bioinformatics (2010); 5(1):68-80.PMID: 20802832.

(65). Haizheng Wang, Xueliang Gao, Yun Huang, Jenny Yang, and Zhi-Ren Liu. P68 RNA helicase is a nucleocytoplasmic shuttling protein. Cancer Research (2009). Dec;19(12):1388-400. Epub 2009 Sep 29. PMID: 19786986.

(64).  Ning Chen, Yun Huang, Lily Yang, Rihe Liu and Jenny J. Yang,  Designing Caspase-3 Sensors for Imaging of Apoptosis in Living Cells. Chemistry. (2009). 15(37):9311-4. PMID: 19655355.

(63). Yun Huang, Yubin Zhou, Hing-Cheung Wong, Yanyi Chen, Yan Chen, Siming Wang, Adriana Castiblanco, Aimin Liu, and Jenny J. Yang. A Single EF-hand Isolated from STIM1 Forms Dimer in the Absence and Presence of Calcium, FEBS J. (2009) 276(19):5589-97. Epub 2009 Aug 20. PMID: 19694801

(62). Yubin Zhou, Teryl Frey, Jenny Yang, Viral Calciomics: Interplays Between Ca2+ and Virus. Cell Calcium (2009).  46 (1): 1-17. Epub 2009 Jun 16. PMID: 19535138.

(61). Ning Chen, Yiming Ye, Jin Zou, Shunyi Li, Siming Wang, Amy Martin, Robert Wohlhueter, and Jenny J. Yang,  Fluorescence complementation via EF-hand interactions, Journal of Biotechnology  (2009). 142(3-4):205-13. Epub 2009 Jun 11. PMID: 19500621.

(60). Angela Holder, April Ellis, Jin Zou, and Jenny J. Yang. Facilitating Chromophore Formation of Engineered Ca2+ Binding Green Fluorescent Proteins. Achieves of Biophysics and Biochemistry (2009). 486(1):27-34. Epub 2009 Apr 7. PMID: 19358822.

(59).  Ning Chen, Jin Zou, Siming Wang, Yiming Ye, Yun Huang, Giovanni Gadda, and Jenny J. Yang, Designing Sensitive Protease Sensors for Living Cell Imaging. Biochemistry (2009). 48(15):3519-26. PMID: 19271729

(58).  Yubin Zhou, Wei Yang, Yanyi Chen, Jie Jiang, Yun Huang, Jin Zou, Monica M. Lurtz, Shunyi Li,  Charles F. Louis, and Jenny J. Yang Calmodulin Mediates the Ca2+-dependent Regulation of Cx44 Gap Junctions. Biophysical Journal (2009). 96(7):2832-48. PMID: 19348766.

(57). Yun Huang, Yubin Zhou, Adriana Castiblanco, Wei Yang, Edward M. Brown, and Jenny J. Yang, Multiple Ca2+ Binding Sites in the Extracellular Domain of Ca2+-sensing Receptor Corresponding to Cooperative Ca2+ Responses, Biochemistry (2009), Dec 22. [Epub ahead of print] 48(2):388-98. PMID: 19102677.

(56).  Yubin Zhou, Wen-Pin Tzeng, Yun Huang, Yiming Ye, Yanyi Chen, Teryl K. Frey and Jenny J. Yang,  A Cysteine-rich Metal-binding Domain from Rubella Virus Nonstructural Protein is Essential for Viral Protease Activity and Virus Replication. Biochemical Journal (2009) 417(2):477-83. PMID: 18795894.

(55). Xue Wang, Michael Kirberger, Guantao Chen, and Jenny J. Yang, Towards Predicting Ca2+–binding Sites with Different Coordination Numbers in Proteins with Atomic Resolution, Proteins: Bioinoformatics, (2009), 75(4):787-98. PMID: 19003991

(54). Shunyi Li, Wei Yang, Anna Wilkins Mannicia, Doyle Barrow Jr., Harianto Tjong, Huan-Xiang Zhou,  and Jenny Yang, Rational design of a conformation-switchable Ca2+- and Tb3+-binding protein without the use of multiple coupled metal-binding sites. FEBS (2008) Oct; 275(20):5048-61. Epub 2008 Sep 10. PMID: 18785925

(53). Michael Kirberger, Xue Wang, Hai Deng,Wei Yang, Guantao Chen, and Jenny J Yang Statistical Analysis of Structural Characteristics of Protein Ca2+ binding sites. Journal Biological Inorganic Chemistry (2008) 130(29):9260-7. 2008. Jul 2. [Epub ahead of print]. PMID:18594878

(52). Michael Kirberger and Jenny J. Yang, Structural Differences Between Pb2+ - and Ca2+-binding Sites in Proteins: Implications with Respect to Toxicity. Journal of Inorganic Biochemistry  (2008) 102(10):1901-9. Epub 2008 Jul 5. PMID:18684507

(51). Jenny J. Yang, Jianhua Yang, Lixia Wei, Wei Yang, Omar Zurkiya, Hui Mao, Fuqian Zhao, Russell Malchow, Shunyi Li, Anna L. Wilkins Mannicia, Shumin Zhao, Jin Zou, Julian Johnson, Xiaoping Hu, Eirk Krogstad, and Zhi-Ren Liu, Rational Design Protein Based MRI Contrast Agents with High Relaxivity Journal of the American Chemical Society (2008), 130(29):9260-7. Epub 2008 Jun 25. PMID:18576649.

(50). Lisa Jones, Wei Yang, Anna L. Wilkins Mannicia, Alice Kearney, Anton P. van der Merwe, and Jenny J. Yang. Rational Design of a novel calcium binding site adjacent to the ligand binding site on CD2 increases its CD48 affinity. Protein Science (2008). 17(3): 439-49.

(49). Yubin Zhou, Wei Yang, Yiming Ye, Yun Huang , Hsiau-Wei Lee, Monica M. Lurtz, Charles F. Louis, and Jenny J. Yang. Identification of the Calmodulin-Binding Domain of Connexin43. Journal of Biological Chemistry (2007). Sep 27;  [Epub ahead of print] 282(48):35005-17.

(48). Yubin Zhou, Wei Yang, Hsiau-Wei Lee, Yiming Ye, Yumei Zhou, Suganthi Suppiah, Teryl K. Frey and Jenny J. Yang. Identification of a Ca2+-Binding Domain in the Rubella Virus Nonstructural Protease. Journal of Virology (2007) Epub 2007 May 2. Jul;81(14):7517-28.

(47). Yun Huang, Yubin Zhou, Wei Yang, Robert Butters, Hsiau-wei Lee, Shunyi Li, Andriana Castiblanco, Edward Brown, and Jenny J. Yang. Identification and dissection of Ca2+-binding sites in the extracellular domain of Ca2+-sensing receptor. Journal of Biological Chemistry (2007). May 3; [Epub ahead of print]. 282(26):19000-10.

(46). Yanling Zhang, Minyong Li, Sekar Chandrasekaran, Xingming Gao, Xikui Fang,  Hsiau-wei Lee,  Kenneth Hardcastle, Jenny Yang, and Binghe Wang. The first boronic acid supramolecular structure that relies on double intermolecular B-N bonds for self-assembly in solid state and in solution.  Tetrahedron (2007). 63:3287-92.

(45).  Jin Zou, Aldebaran M. Hofer, Monica Lurtz, Giovanni Gadda, April L. Ellis, Ning Chen, Yun Huang, Angela Holder, Yiming Ye, Charles Louis, Kristy Welshhans, Vincent Rehder, and Jenny J. Yang. Developing Sensors for Real Time Imaging of High Calcium Concentrations. Biochemistry 2007 Oct 9; [Epub ahead of print]. Oct 30;46(43):12275-88. PMID: 17924653.

(44). Jenny J. Yang, Roland Pochet, and Arthur S. Nolen.  Calcium, diversity and evolution, Meeting report of calcium binding proteins in normal and transformed cells and Diseases, Calcium Binding Protein (2006) 1(3), 170-174.

(43).Yuan Liu, Qiao Tong, Yubin Zhou, Hsiau-Wei Lee, Jenny J. Yang, Hans-Jörg Bühring, Yi-Tien Chen, Binh Ha, Celia X.-J. Chen and Ke Zen. Functional Elements on SIRPα IgV Domain Mediate Cell Surface Binding to CD47 Journal of Molecular Biology   (2006) 365(3):680-93. Epub 2006 Oct 3.

(42). Jenny J. Yang. Calmodulin, the Surprises Continue. Calcium Binding Protein (2006), 1 (2),  65-66.

(41). Yubin Zhou, Michael Kirberger, Hsiau-Wei Lee, Gayatri Ayalasomayajula, Wei Yang, and Jenny J.Yang. Prediction of EF-hand calcium binding proteins and Analysis of Bacterial EF-Hand Proteins. Proteins: Structure, Function, and Bioinformatics (2006), 65(3):643-55.

(40). Anna Wilkins Maniccia, Wei Yang, Shun-yi Li, Julian A. Johnson and Jenny J. Yang. Using Protein Design to Dissect the Effect of Charge Residues on Metal Binding and Protein Stability. Biochemistry, (2006) 45(18):5848-56.

(39). Hai Deng, GT Chen, Wei Yang and Jenny J. Yang. Identifying and Predicting Calcium Binding Sites in Proteins using Graph and Geometry Algorithms. Proteins (2006), 64(1):34-42.Apr 14.

(38). Amy R. Carroll, Wei Yang, Yiming Ye, and Jenny Jie Yang. Amyloid Fibril Formation in a Domain of Rat Cell Adhesion Molecule. Cell Biochemistry and Biophysics (2006), 44(2):241-50.

(37). Chunru Lin, Liuqing Yang, Jenny J. Yang, Youliang Huang, and Zhi-Ren Liu, ATPase/Helicase Activities of p68 RNA Helicase are Required for Pre-mRNA Splicing but not for Assembly of the Spliceosome.  Molecular and Cellular Biology (2005). 25 (17) 7484-7493.

(36). Wei Yang, Anna Wilkins, Shunyi Li, Yiming Ye, and Jenny J Yang. The Effects of Ca2+ Binding on the Dynamic Properties of a Designed Ca2+-binding Protein.  Biochemistry (2005), 44, 8267-8273.

(35) Jin Zou, Yiming Ye, Kristy Welshhans, Monica Lurtz, April Ellis, Charles Louis, Vincent Rehder and Jenny J. Yang. Expression and Optical Properties of Green Fluorescent Protein Expressed in Different Cellular Environments. Journal of Biotechnology (2005). 119(4):368-78.

(34). Yiming Ye, Hsiau-Wei Lee, Wei Yang, and Jenny J. Yang. Calcium and Lanthanide Affinity of the EF-loops from the C-terminal of Calmodulin. Journal of Inorganic Biochemistry (2005), 99, 1376-1383.

(33).     Yiming Ye, Hsiau-Wei Lee, Wei Yang, Sarah Shealy, and Jenny J. Yang. Probing site-specific metal binding affinity of EF-hand Proteins by Grafting. Journal of the American Chemical Society (2005), 127 (11), 3743-50. PMID:15771508.

(32). Wei Yang, Anna Wilkins, Yiming Ye, Zhi-ren Liu, Shunyi Li, Jeffrey L. Urbauer, Homme W. Hellinga, Alice Kearney, Anton P. van der Merwe and Jenny J. Yang. Design of a Calcium-Binding Protein with Desired Structure in a Cell Adhesion Molecule. Journal of the American Chemical Society (2005), 127 (7), 2085-2093. PMID: 15713084.

(31).  Jenny J. Yang and Wei Yang, Calcium Binding Proteins Encyclopedia of Inorganic Chemistry,  Bruce King (Eds.) 2nd Edition, John Wiley & Sons, Ltd (2005).

(30).  Liuqing Yang, Jenny Yang, Youliang Huang, and Zhi-Ren Liu, Phosphorylation of p68 RNA helicase regulates RNA binding by the C-terminal domain of the protein. BBRC (2004), 314(2), 622-630.

(29).  Wei Yang, Lisa Jones, Leanne Isley, Yiming Ye, Hsiau-Wei Lee, Anna Wilkins, Zhi-ren Liu, Homme W. Hellinga, Russell Malchow, Mohammed Ghazi and Jenny J. Yang. Rational Design of a Calcium Binding Protein. Journal of the American Chemical Society, (2003), 125(20), 6165-71. PMID:12785848.

 (28). Anna Wilkins, Wei Yang, and Jenny J. Yang, Structural Biology of the Cell Adhesion Protein CD2: From Molecular Recognition to Protein Folding and Design. Current Protein and Peptide Science (2003), 4, 367-73.

(27)  Yiming Ye, Sarah J. Shealy, Hsiau-Wei Lee, Ivan Torshin, Robert Harrison, and Jenny J. Yang “A Grafting Approach for Site-Specific Metal Binding Affinity of EF-hand Proteins.” Protein Engineering (2003), 16(6), 429-34.

(26).  Jenny J. Yang, Amy Gawthrop, and Yiming Ye “Obtaining Site-specific Calcium –binding Affinities of Calmodulin” Protein and Peptide Letter (2003), 10 (4), 331-345.

(25). Hsiau-wei Lee, Wei Yang, Yiming Ye, Zhi-ren Liu, John Glushka and Jenny J. Yang, Isolated EF-loop III of Calmodulin in a Scaffold Protein Remains Unpaired in Solution Using Pulsed-field-gradient NMR Spectroscopy. BBA (2002), 1598, 80-87.

(24).  Anna L. Wilkins, Yiming Ye, Wei Yang, Zhi-ren Liu, Sarah Shealy, Hsiau-wei Lee, and Jenny J. Yang. Metal-binding Studies for a de novo Designed Calcium-binding Protein. Protein Engineering (2002), 15(7), 571-574.

(23). April L. Ellis, J. Christian Mason, Hsiau-wei Lee, Lucjan Strekowski, Gabor Patonay, Hoseob Choi, Jenny J. Yang. Design, Synthesis, and Characterization of a Calcium-Sensitive Near Infrared Dye. Talanta (2002), 56, 1099-1107.

(22). Wei Yang, Hsiau-wei Lee, Homme Hellinga and Jenny J. Yang. Structural Analysis, Identification, and Design of Calcium-Binding Sites in Proteins. Proteins (2002), 47, 344-356.

(21). Jenny J. Yang, Haidong Yang, Yiming Ye, Harry Hopkins & Gary Hastings. Temperature-Induced Formation of a Non-native Intermediate State of the all Beta-sheet Protein CD2. Cell Biochemistry and Biophysics (2002), 36, 1-18.

(20). Yiming Ye, Hsiau-Wei Lee, Wei Yang, Sarah J. Shealy, Anna L. Wilkins, Zhi-ren Liu, Ivan Torshin, Robert Harrison, Robert Wohlhueter and Jenny J. Yang. Metal Binding Affinity and Structural Properties of an Isolated EF-loop in a Scaffold Protein. Protein Engineering (2001), 14(12), 1001-1013.

(19). Jenny J. Yang, Yiming Ye, Amy Carroll, Wei Yang, and Hsiau-wei Lee. Structural Biology of the Cell Adhesion Protein CD2: Alternatively Folded States and Structure-function Relation. Current Protein and Peptide Science (2001), 2 (1), 1-17. 

(18).  Jenny J. Yang, Amy R. Carroll, Wei Yang, Yiming Ye, and, Christina Nguyen. Nonnative Intermediate State of Acid-Stable beta-Sheet Protein. Cell Biochemistry and Biophysics (2000) 33, 253-273.

(17). Wei Yang, Hsiau-wei Lee, Homme Hellinga, Michelle Pu and Jenny J. Yang. Identifying and Designing Calcium Binding Sites in Proteins by Computational Algorithm. Computational Studies, Nanotechnology, and Solution Thermodynamics of Polymer Systems. Kluwer Academic/Plenum Publishers. 127-138, 2000.

(16).  Wei Yang, Hsiau-wei Lee, Zhi-ren Liu, Homme Hellinga and Jenny J. Yang. Criteria for  Designing a Calcium Binding Protein. Peptides: The Wave of the Future, R. A. Houghten & M. Lebl. (Eds.), Escom Leiden (2001), 811-813.

(15).  Yiming Ye, Annie Lin and Jenny J. Yang. Calcium Binding Properties of EF-loops in a Beta-sheet Protein. Peptides: The Wave of the Future, R. A. Houghten & M. Lebl. (Eds.), Escom Leiden (2001), 450-451.

(14). Wei Yang, Tom Tsai, Mark Kats, & Jenny Jie Yang. Peptide Analogs from E-Cadherin with Different Calcium Binding Affinity. Journal of Peptide Research (2000) 55, 203-215.

(13). Xin Liu, Jenny J. Yang, Mohamad Ghazi & Teryl Frey. Characterization of the Zinc Binding Activity of the Rubella Virus Nonstructural Protease. Journal of Virology (2000) 74, 5949-5956.

(12). Wei Yang. Yiming Ye and Jenny Jie Yang. A Sensitive Method for Selecting Calcium-binding Proteins. Luminescence Forum, (1999) 5, 4-8.

(11).  Wei Yang and Jenny Jie Yang  Investigation of Conformational Properties of  Ca(II)-binding Peptides in Cell Adhesion Molecules. Peptides: Frontiers of Peptide Science, J. Tam & Kaumaya, P.T.P, R.S. (Eds.), Escom Leiden (1997),112-113.

(10).  Jenny Jie Yang, van den Berg, B., Pitkeathly, M., Smith, L., Bolin, K.A., Keiderling, T., Redfield, C., Dobson, C. M., & Radford, S.E. Native-like Secondary Structure in a Peptide from the alpha-domain of Hen Lysozyme. Structure, Folding & Design (1996) 25, 473-484.

(9). Jenny Jie Yang, Matthias Buck, Maureen Pitkeathly, Michael Kotik, Donald T. Haynie, Christopher M. Dobson, and Sheena E. Radford. Conformational Properties of Four Peptides Spanning the Entire Sequence of Hen Lysozyme.  Journal of Molecular Biology (1995) 252, 483-491.

(8). Mary Gregoriou, Pam F. Jones, John F. Timms, Jenny J. Yang, Sheena E. Radford and Anthony R. Rees.  Physicochemical Characterization of the Cytoplasmic Domain of the EGF Receptor and Evidence for Conformational Changes Associated with its Activation by Ammonium Sulfate. Biochemistry Journal  (1995) 305, 667-678.

(7). Jenny Jie Yang and Harold E. Van Wart. Kinetics of Hydrolysis of Dansyl-Peptide by Thermolysin: Analysis of Fluorescence Change and Determination of Steady-State Kinetic Parameters. Biochemistry  (1994), 33, 6508-6515.

(6). Jenny Jie Yang, Dean R. Artis, and  Harold E. Van Wart. Differential Effect of Halide Anions on the Hydrolysis of Different Dansyl-Substrates by Thermolysin. Biochemistry  (1994), 33, 6516-6523.

(5). Jenny Jie Yang, Maureen Pitkeathly, and Sheena E. Radford. Far UV Circular Dichroism Reveals a Conformation Switch in a Peptide Fragment from the Beta- Sheet of Hen Lysozyme. Biochemistry  (1994) 33, 7345-7353.

(4). Jenny Jie Yang, Maureen Pitkeathly, Christina Redfield, Christopher M. Dobson and Sheena E. Radford.  Using Peptide Models to Dissect the Protein Folding Pathway. Peptides: Chemistry, Structure and Biology, Kaumaya, P.T.P. and Hodges, R.S. (Eds.), Escom Leiden (1995) 825-826.

(3). Jenny Jie Yang, Maureen Pitkeathly, Christina Redfield, Christopher M. Dobson and Sheena E. Radford.  Tracing Protein Folding Pathway by Using Peptide Models.  Perspectives on Protein Engineering  60-61 (1994).

(2).  Jenny Jie Yang, Maureen Pitkeathly, and Sheena E. Radford.  Investigation of the Folding of beta-sheet Peptide Fragment of Lysozyme by Circular Dichroism and Size Exclusion Chromatography. Proceedings of 5th International Conference on Circular Dichroism 80-84 (1993).

(1). Jie Yang and Shi-lin Tan. Determination of Trace Elements by Anodic Stripping Voltammetry. Journal of Xiangtan Science (1986) 4, 64-70.